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To NRT or Not to NRT – That is the Question

Dr_Hays
Mayo Clinic
2 7 210

When I first meet with patients, a concern I often hear is whether it is okay to use nicotine replacement therapy (NRT).  They ask, “Doc, why should I use nicotine if I’m trying to get off the nicotine?  This is a great question!

 

First it is important to note that nicotine is NOT the harmful substance in cigarettes.  Rather it is all the other compounds and chemicals in cigarettes and smoke that cause the damage.  Secondly, nicotine in its medicinal form has a very low addictive potential, especially when we compare it to the free-based nicotine in tobacco.  You can learn about the neurobiology of tobacco addiction from my past blogs (Part I; Part II).  When we use NRT to assist with quitting smoking, we are satisfying the brain’s desire for nicotine without maintaining the addiction and without exposing our body to the other harmful substances in cigarettes such as carbon monoxide, hydrogen cyanide, benzene, and formaldehyde.

 

In order for NRT to be the most effective, we find it is critically important to do two things: accurately match the NRT dose to the amount of nicotine your brain is accustomed to receiving from cigarettes and ensuring the medication is used for the recommended amount of time – which can be several months for some individuals.  There are currently five NRT products available in the United States including the long-acting patch and the faster acting nicotine gum, lozenge, inhaler, and nasal spray.  Research shows that using a combination of smoking cessation medications – using a fast acting product during triggers while wearing the patch throughout the day - can greatly improve quit rates.  

 

While there is strong evidence to support the use of NRT during the quit process, it is a personal decision.  Your healthcare provider can be a great resource to help you find a dose and combination that will not only be effective in controlling cravings, but also be a plan with which you are comfortable.  You will find many different philosophies and experiences within the Ex Community and I encourage you to explore them all.  Most importantly, consider your own thoughts and feelings when deciding to use medicinal nicotine on your smoke-free journey.

7 Comments
Giulia
Member

"...nicotine in its medicinal form has a very low addictive potential,"  even when you COMBINE them?    "This is in part because of lower doses and slower absorption of nicotine obtained from NRT products"

"Long-term use of nicotine replacement treatment was significantly more likely in more dependent smokers." (Hajek P1, McRobbie H, Gillison F.)

"Continued use of NRT at week 15 was related to rate of delivery of nicotine from the products - 2% for patch, 7% for gum and inhaler, 10% for spray" (West R1, Hajek P, Foulds J, Nilsson F, May S, Meadows A.)

Having been on this site for 8 years I've certainly read quite a number of posts about people having to "wean" themselves off the gum.  Behavioral only?  Or chemical dependence?  Combination of the two?  Just part of that 7% crowd?

Just found a really intersting article in Scientific America .  Don't know if that journal is well-regarded these days or not.)  Interesting that one study shows the potential for nicotine's benefits regarding Parkinsons and Alzheimers and then there's a rather opposite point of view:    harmful effects of nicotine (I'd be really interested in hearing your opinion on the latter study.) 

Obviously the ideal is to use the products as directed. 

JonesCarpeDiem

Regarding claimed success rates.

On the double the success claim using nrt's?

     " I traced this claim to a Department of Health web page, which also claimed a 15 per cent success rate at 12 months for NRT. The evidence that was supposed to demonstrate this 15 per cent success rate and the "four times more likely to quit" phenomenon was not listed in the footnotes, so I wrote to the Department to ask for it.

  
   It took over three months to get the information   [3]

When that information was finally forthcoming, the figures showed a 6.5% quit rate for those using NRT, and a 6% quit rate for those going "cold turkey, i.e. without using NRT." So much for the "15% success rate" and "four times more likely" claims." (see following link)

http://tctactics.org/index.php/Pharma

JonesCarpeDiem

After using NRT's for the suggested length of time, at 6 months, users went back to smoking at the same rate as non users.

http://whyquit.com/whyquit/A_OTCPatch.html

Pops
Member

During this quit, I started my quit on the 21 mg NRT patch.  I turned it down to the 14 mg after one week and used that for about 4 weeks.  I never went to the 7 mg, and I feel fine.  I never really suffered any withdrawls or excessive craves that I hadn't experienced in previous quits.

As for me, I think it is all about the mental frame of mind @ the time of your quit.  Why am I quitting?  Am I willing to put up with relentless mental tug'o;war?  Will I accept feedback?  All these are factors that I addressed before I threw away my smokes and returned to this site.

Today, I am a happy smoke free, and nicotine free EX smoker with 50 relatively easy days of freedom behind me.

Pops

Dr_Hays
Mayo Clinic

Thank you for the thoughtful comments, Giulia and Dale.  I'd like to offer an analogy about research, without getting too bogged down in individual citations or specific statistics.  

When we ask a research question and conduct a study to determine the answer, it is like putting together a jigsaw puzzle.  Each study is one piece of the puzzle from which we can draw some conclusions.  As more research is conducted, we add these pieces together to develop a better understanding of the larger picture. 

This meta-analysis of 150 studies on nicotine replacement use among 50,000 participants give us a bigger picture understanding of the benefits of NRT in people attempting to stop smoking: http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD000146.pub4/full .

As I mentioned in my blog, there is strong evidence to support the use of NRT for a designated period of time when stopping smoking.  However, determining if it is the right fit for you is an important step in the quit planning process.  A primary care provider or a Tobacco Treatment Specialist can help you determine the needed length of time to use these effective medications.  

JonesCarpeDiem

Thanks.

I'm not against NRT's but I question some of the rate of success claims.

It's more what you believe. If I told myself that eating broccoli on Mondays, Wednesdeays and Fridays was going to keep me quit, I believe it would work because I believed it would.

Ed55
Member

What Dale said is spot on as usual. 

I read the published results of one clinical trial touting double the success rate with some form of nrt.

Funded by Phizer.

About the Author
An expert in tobacco use and dependence, Dr. Hays has authored and co-authored over 70 peer-reviewed scholarly articles and book chapters on various aspects tobacco dependence and its treatment. Since joining the Nicotine Dependence Center in 1992, he and its staff have treated more than 50,000 patients for tobacco dependence.